Oral administration of eucalyptol reduces cell migration and pain-like behavior in zymosan-induced arthritis mice

Rheumatoid arthritis (RA) is an inflammatory disease that utilizes nonbiologic and biologic drugs for appropriate management. However, high cost, adverse effects, reduced effectiveness, risk of infection have stimulated the search safer more efficacious therapeutic strategies. In present study, we aimed to evaluate anti-inflammatory analgesic properties eucalyptol in experimental model arthritis. Mice were administered zymosan or saline intra-articularly. One hour before administration, mice treated with oral (200-400 mg/kg) vehicle. Cell influx, neutrophils, lymphocytes, monocytes measured joint exudates. Joint pain was assessed using paw-pressure tests. Orally (200 400 significantly cell as well monocytes, when compared control. Eucalyptol at a dose mg/kg reversed demonstrated activity (60%); however, 200 failed alter pain. These results indicate promotes subjected zymosan-induced